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Essay / Retinitis Pigmentosa Essay - 1955
Retinitis pigmentosa (RP) is a hereditary disease grouping diseases of the retina that present features of rod and cone dystrophy. These defects appear to cause apoptosis within rod photoreceptors and, due to their location and peripheral functions, this leads to symptoms of night blindness during childhood and mid-adulthood with impaired visual field progressively restricted, and by the age of 40 the majority of patients with RP are registered as legally blind. In terms of management of RP, the only clinical intervention is to advise patients to increase vitamin A levels in their diet, which has been shown to slightly reduce disease progression. 1 However, at present, there does not appear to be a treatment for the disease or management to restore vision. Previously, research has focused on gene therapy, particularly the RPE65 gene, which has received much attention in the literature and seems plausible in theory, especially considering that RP is a genetic disease. and which has shown some success in animal studies.2 The limitation of gene therapy research is that the results might not be transferable to humans, especially since 45 different genes have been identified , which appears to account for 60% of RP cases, of which 40% are caused by unidentified genes3 – thus proving It is very difficult to introduce treatment based on gene therapy into clinical practice due to the variability and differences between genetic forms of retinitis pigmentosa. Given the possible difficulties encountered with gene therapy, stem cell technology offers a promising alternative approach, particularly with RP. Although the etiology of the disease is not fully known... middle of article... cellular research lies in the possibility of transforming stem cells into leaves for transplantation, which, looking at the research, has the potential to significantly improve visual function and therefore quality of life in patients with retinitis pigmentosa. In conclusion, in terms of the future of retinitis pigmentosa, treatment in the form of stem cell therapy appears very promising. Even if treatment is not imminent, the next step is to apply the methods described in human trials to assess whether the same levels of improvement and, more importantly, safety can be achieved. Although in its infancy, stem cell therapy represents a beacon of hope for those suffering from the disease as it could pave the way for both disease prevention and, more importantly, cure. reversal of blindness caused by photoreceptor damage..