Introduction: Science of bioprocess engineering is a broad scientific field, where four different major subjects such as chemical engineering, molecular biology and biotechnology, biomedical science and materials engineering; working together in harmony to solve many difficult problems that the scientist may face in the fields of biomedical sciences, energy products, nutrition and the design of devices such as bioreactors [1], modified and added. Bioreactor is one of the most familiar words in the field of bioprocess engineering. books. That is, a place designed to be suitable for the growth of specific types of bacteria, fungi or other microorganisms by providing the conditions necessary for their growth [2]. These microorganisms carry out biochemical processes that produce materials useful to humanity, such as certain types of drugs, enzymes and fuels. In this case, the fuel made by microorganisms is called biofuel [3]. Biofuel is often environmentally friendly and has many advantages, such as it is cheap, it is a renewable energy resource and it is easy to produce. On the other hand, it has some negative points, such as the fact that it takes a long time to produce some biofuel waste when we use the normal method to produce it. In this project, some design points of bioreactor devices, methods and technologies and their use to produce biofuel will be addressed. Uses of Bioprocess Engineering: 1-Some important points before starting the bioreactor project: First of all, and before starting the design or work. on any bioreactor, certain points related to the future of the bioreactor project must be clarified. One of these points is what is the result that we want to achieve, which must be a very useful thing and...... middle of paper ...... it is whey. The weakness of this method is the reduction in optical switching efficiency. The fourth production method is the dark fermentation system which uses fermenting bacteria which can produce hydrogen at any time without light or oxygen. The main disadvantage of this mode is that the output gas mixture contains carbon CO2 which must be separated. There is also a decrease in H2 production. Conclusion: In conclusion, due to the limitation of fossil fuels and the resulting damage, today's world really needs to clean up renewable energy resources, save the planet and have a save the future . This own resource can be easily found in biotechnology and bioprocess engineering studies which include many different researches and innovative solutions for the most important condition of nourishment and development..