Pathogenic microbes in fish represent a serious problem and major concern due to lack of income, decline in global aquaculture and increasing human diseases associated (Lafferty et al. 2015). Consumption of clean African catfish (Clarias gariepinus) is booming in rural and urban centers of Nigeria (FDF, 2007; Emikpe et al., 2011). But there are few statistics on the bacterial load of African catfish sampled from ponds and natural waters (Emikpe et al., 2011). The need for passive and periodic monitoring of the presence of pathogenic microbes in fish is vital. The microbial diversity of drinking water may also include a complex vegetation of microorganisms, as well as purely aquatic pathogens and other components from human, animal, and plant sources. Say no to plagiarism. Get a tailor-made essay on “Why Violent Video Games Should Not Be Banned”? Get an original essayA number of pathogenic microbes found in fish are facultative (Nayak 2010) and capable of existing continuously in water for long intervals of time, making their presence difficult to prevent. Examination of pathogenic microorganisms should be carried out often to assume the occurrence of a pathogenic attack. The success of disease control, such as prevention and treatment, is greatly influenced by the accuracy of disease analysis in fish. The scale of human activities has been established to exert destructive consequences on coastal waters. Considering that many fish utilize food particles from large volumes of water, if these waters become infected, the risk that enteric pathogens from infected individuals may be present is excessive and these contaminants may potentially be concentrated using the filtering nature of fish. . Fish is an important part of the daily weight loss program of human beings in many countries and has been one of the main dietary resources of man for many centuries. Fish are a good source of animal protein, rich in minerals, amino acids and essential fatty acids. Therefore, fish constitute a valuable contribution to the diet of malnourished populations. The demand for fish is increasing significantly as it is the cheapest source of animal protein. But fish can face microbial infection of their natural habitat and their processing products can cause microbial infections and food poisoning. In the natural habitat, microorganisms are usually found on the entire external surface (pores, skin and gills) and in the intestines of fish. The bacterial flora of freshly caught fish depends on the environment in which they were caught. In addition, it was clarified that the level of contamination of a fish at the time of its capture depends largely on the microbiological quality of the water and the environment in which it was captured. Water bodies can be extremely polluted by animal and human waste thus containing several micro-organisms which can further contribute to its pollutants. The presence of various microbes that may be particularly pathogenic to humans in fish is most suggestive, but its importance in the initiation of human diseases is unknown. But the presence of potential human pathogens suggests the fish was eaten raw, undercooked and, if mishandled, could cause illness..