Medications have been used to aid sleep for years and years. There are many types of drugs that people use; choosing between non-traditional medications such as herbs and vitamins, while others opt for the traditional approach of using prescription medications. This article will inform and analyze the drug Zolpidem. Zolpidem is used in the treatment of insomnia. Insomnia is often thought of as prolonged difficulty falling or staying asleep. This article will present the background of Zolpidem; by tracing the history of drugs. The path of drugs in the body or pharmacokinetics will also be explained. The process of absorption, distribution and inactivation will be covered in pharmacokinetics. The pharmacodynamics of the drug will be covered; explaining the sites of action and areas of the brain that are affected by the drug. The potential for tolerance and dependence to develop will also be examined. The level of toxicity of Zolpidem as well as potential side effects. The effectiveness of the drug as a form of psychotherapy will also be analyzed. Overall, this article will give a detailed overview of the Zolpidem drug. Starting with the history of the drug, drug interactions in the body and the effectiveness of the drug for its use. Since Zolpidem is a prescription medication, this overview should be informative and analytical of the medications' abilities to produce the desired effects in the treatment of insomnia. Background Zolpidem is a non-benzodiazepine hypnotic of the imidazopyridine class; which means that the drug is a GABAa receptor agonist (Source 7). Zolpidem was introduced in the early 1900s and helped advance treatments for insomnia. Non-benzodiazepine Zolpide...... middle of paper ......-436.Mattoo, S., Gaur, N. and Das, P. (2011). Zolpidem withdrawal delirium. Indian Journal Of Pharmacology, 43(6), 729-730.Mortaz Hejri, S., Faizi, M. and Babaeian, M. (2013). Suicide attempt induced by zolpidem: report of a case. Daru: Journal of the Faculty of Pharmacy, Tehran University of Medical Sciences, 21(1), 77.Neubauer, D. (2009). Current and new thinking in the management of comorbid insomnia. The American Journal Of Managed Care, 15 SupplS24-S32. Otmani, S., Demazières, A., Staner, C., Jacob, N., Nir, T., Zisapel, N. and Staner, L. (2008). Effects of extended-release melatonin, zolpidem and their combination on psychomotor functions, memory recall and driving skills in healthy middle-aged and elderly volunteers. Human Psychopharmacology, 23(8), 693-705 Yang, L. and Deeks, E. (2012). Zolpidem sublingual (Edluar™; Sublinox™). CNS Medications, 26(11), 1003-1010.