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  • Essay / Immunological Theory of Aging - 763

    Throughout history, humanity has been obsessed with finding a cure for any disease or disorder that could disrupt or hinder their short lives, especially those aimed at escaping the aging process. As society became increasingly interested in eternal beauty and longevity, the race to discover the main contributing factor to aging began in the early 1900s. Amidst this quest, several biological theories had been developed. Among these theories is the immunity or immunological theory. This article will discuss the immunological theory of aging by explaining the theory, giving a history of its origin, and a description of the subsequent development within the evolution of the theory. Aging, as expounded in the theory of immunity, has been described as a preprogrammed accumulation. damage, degradation and decline in immune system function caused by oxidative stress due to the Hayflick limit or biological clock (Touhy and Jett, 2012). This limit refers to the idea that aging is the result of cells and organisms containing a genetically predetermined lifespan (Touhy and Jett, 2012). This suggests that relative to a cell's instinct to proliferate, aging becomes more prominent in an individual when cells reach the limit, introducing cellular errors of imperfect proliferation that result in further damage. Additionally, no cell in the body appears to be above this concept, including the B cells and T cells of the immune system. In fact, cellular errors within the immune system have been found to cultivate an autoregressive phenomenon in which normal cells are misidentified as foreign and are consequently destroyed by the body's own immune system (Touhy and Jett, 2012). The latter...... middle of paper ...... protecting them from other dangerous exogenous substances, a price is then paid with a weakened dysregulated immune system, becoming susceptible to aging and age-related diseases age (DeVeale, Brummel & Séroude, 2004). Despite ongoing research into the complex process of aging, humans continually age, both physically and mentally. However, just as the immune system is part of the complexity of being human, so is aging (Effros, 2005). Works CitedDeVeale, B., Brummel, T., & Seroude, L. (2004). Immunity and aging: the enemy within?. Aging Cell, 3(4), 195-208. Effros, R.B. (2005). Roy Walford and the immunological theory of aging. Immunity and Aging, 27-3. doi:10.1186/1742-4933-2-7Touhy, T. & Jett, K. (2012). Ebersole & Hess' Toward Healthy Human Needs and the Nursing Response (8th ed.). St. Louis: Elsevier Mosby. 36-37 pages. [ISBN 978-0-323-07316-5].