Based on the results of numerous tests performed based on the patient's history of foamy urine with significant edema over a period of up to 5 days, the patient was diagnosed with the nephrotic syndrome. This is a condition caused by a leak in the filtration part of the kidneys, causing a large amount of protein to leak from the blood into the urine. This is mainly due to fluid retention called edema, which results from low protein levels in the blood. This occurs due to abnormal functioning or part of the kidney (glomeruli). This syndrome can be caused by many diseases coming together to cause or form a particular disease; These causes range from minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis (FSGS) and other conditions, disorders of the glomeruli. Membranous nephropathy also known as membranous nephritis or membranous glomerulonephritis, causes disease only in adults and very rare in children. Leakage occurs due to thickening of the glomeruli membrane which is the filter of the glomeruli. Focal segmental glomerulosclerosis is a cause due to the formation of small scars (sclerosis) on certain kidney glomeruli. Another form of nephrotic cause is minimal change due to no virtual change detected in the glomeruli on microscopic examination. This causes the syndrome in 9 children under 5 years old out of a total of 10. The pathophysiology of nephrotic syndrome figure 4According to the test results, the patient's syndrome is caused by one or the other of the two; minimal change and focal segmental glomerulosclerosis. The pathophysiologies of the disease are a primary glomerular defect, circulating permeability factor and inhibitors. The primary glomerular defect of nephrotic syndrome results in leakage of high molecular mass proteins equivalent to the size of albumin of approximately 66 kD, with hemostatic proteins of similar size also being excreted pathologically in the urine (Eddy AA and Symons JM , 2003). . Due to these excretions; significant loss of important coagulation regulatory proteins such as antithrombin and protein S. As mentioned above; Hypoalbuminemia is an event primarily due to urinary protein losses. In response to this, hepatic albumin synthesis has increased but is still insufficient to prevent the fall in serum albumin concentration. Proteinuria, nephrotic proteinuria is almost invariably due to glomerular disease.