Pseudoexfoliation syndrome (PXF) is a pathological and age-related accumulation of abnormal fibrillar deposits also on various ocular structures with extraocular tissues. With age, the extracellular matrix can affect up to 20% of the elderly population. Although the specific synthesis and pathophysiology of PXF syndrome is still unknown, the concept of elastotic process has recently been established by the discovery of the lysyl oxidase-like 1 (LOXL 1) gene which is a major risk factor in people with PXF syndrome. PXF syndrome and PXF glaucoma. (Thorleifsson et al., 2007). Finnish ophthalmologist John Lindberg first described PXF in 1917 in his doctoral dissertation. In the context of a newly developed slit lamp, it defined as grayish spots and changes on the lens and on the pupillary rim of the iris in 50% of patients with chronic glaucoma. Prevalence rates vary according to populations such as: the general population, patients with cataracts, patients with severe glaucoma, people over a certain age. The prevalence also depends on the examiner and the method (mydriasis or not, early stages or not). Its prevalence is significantly determined between countries and even within regions or between ethnic groups within many countries. Low levels of PXF have been found in the Eskimos of Greenland (0%), India (4.2% in patients over 70 years of age), the eastern United States (5% in patients between 75 and 85 years), in Germany (1.5% in patients aged 70 to 79 and 6.3% in those aged 80 to 89) and in Great Britain (2% in patients aged 70 aged 79 and 5.4% among those aged 80 to 89) (Vesti and Kivela, 2000). In contrast, high frequencies were reported in Iceland (31.5%), Finland (>20%), Say no to plagiarism. Get a tailor-made essay on “Why violent video games should not be banned”? Get the original essay In southwestern Greece, in a cross-sectional study of patients admitted to hospital for neck surgery cataract, we found that the prevalence of PXF syndrome was 27.9% (Andrikopoulos et al., 2009). Pseudoexfoliation syndrome has been associated with cataract progression, increased intraocular pressure, and intraoperative difficulties such as zonular or posterior capsule rupture, poorly dilated pupils, vitreous loss, and reaction postoperative fibrinoid or dislocation of intraocular lens implants. This is the most common identifiable cause of open-angle glaucoma, pseudoexfoliation glaucoma. Later, it is characterized by poor prognosis than primary open-angle glaucoma, rapid progression and higher resistance to medical treatment of glaucoma. The definitive clinical diagnosis of PXF can only be confirmed at the late stages of classic PXF (fibers in both zones) and at the stage of mini-PXF (focal defects in the upper nasal precapsular layer). Next to the lens, deposits of PXF material are most visible at the pupil margin. Other clinical signs during slit lamp examination are loss of melanin from the peripupillary pigment epithelium of the iris, transillumination defects in the area of ​​the iris sphincter, poor mydriasis, posterior synechiae, zonular weakness, deposition and dispersion of melanin (on iris structures). anterior segment) after dilation of the pupil. It appears that different epithelial and mesenchymal cell types may be associated with disordered synthesis of extracellular fibrillar substance in..