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Essay / Chronic wasting disease - 1491
Chronic wasting disease is a highly transmissible and fatal neurodegenerative disease that affects deer in North America (Belay et al., 2004; Saunders et al., 2012). There are only four types of deer affected by this disease, namely elk, mule deer, white-tailed deer and moose (Chronic Wasting Disease Alliance). It has been classified as transmissible spongiform encephalopathy (TSE), otherwise known as prion disease (Belay et al., 2004). A prion is an irregular pathogen that causes the abnormal folding of specific proteins called prion proteins. These proteins are mainly located in the brain (Chronic Wasting Disease Alliance). Abnormal folding of this protein causes neurodegenerative diseases in various species, including humans, sheep, cattle, and deer (Abrams et al., 2011). The prion diseases to which chronic wasting disease is linked are Creutzfeldt-Jakobs disease present in humans. , bovine spongiform encephalopathy (BSE) in cattle and scrapie in sheep (3,4). These diseases are grouped together because they share certain characteristics such as long incubation periods, spongiform changes associated with neural loss, and prevent the induction of inflammatory responses (Chronic Wasting Disease Alliance). An animal infected with CWD will have neural loss, astrogliosis. , which corresponds to an abnormal increase in the number of astrocytes in the brain, and spongiform lesions (Abrams et al., 2011). Infected particles spread throughout the body, including the brain, spinal cord, eyes, peripheral nerves, and lymphoreticular tissues (Belay et al., 2004). However, most of the infection is localized in the central nervous system. It is currently unknown how chronic wasting disease originated. deer or elk are tested before consuming the meat to avoid ingestion of contaminated meat (Chronic Wasting Disease Alliance). Many studies are currently underway on the potential effects of chronic wasting disease on human health. Until now, CWD has only been transferred outside the deer family in the laboratory by intracerebral injections. There have been no reports of an increase in human prion diseases in CWD-endemic areas, and there is currently no evidence that humans can contract the disease. Due to the long incubation period of CWD, more studies and years of follow-up are needed to fully determine whether human health may be affected by this disease. However, as of yet, there is no evidence that humans or even other animals are affected by chronic wasting disease..