Although both texts include men of questionable science, their methods of experimentation were different. Determined to separate the two sides of man, Jekyll took it upon himself to be the lab rat. He was fully aware of the risks involved in self-experimentation, for he states: “I knew well that I risked death; for any drug that so powerfully controlled and undermined the very fortress of identity could, by the slightest qualm of overdose or by the slightest inopportunity at the moment of exposure, completely obliterate that immaterial tabernacle that I intended to change. But the temptation of a discovery so singular and profound ultimately overcame the suggestions of disquiet” (44). Despite all the dangerous possibilities, Jekyll's drive to discover science pushed him forward. While Jekyll's methods were more practical, Rappaccini took more precautions. Rappaccini took all necessary measures to avoid any harm to himself. For example, when spending time in his poisoned garden, he “…protected his hands with a pair of thick gloves…and placed a sort of mask over his mouth and nostrils…” (2). Rappaccini preferred to carry out his experiments on other people like Beatrice or Giovanni, rather than on himself. Another difference between Jekyll and Hyde and Rappaccini's Daughter is the terms of isolation. Jekyll and Beatrice were kept apart from society, but for different reasons.