Evolutionary developmental biology (evo-devo) was established in the early 1980s as a distinctive field of study to characterize the new synthesis of the evolutionary hypothesis (Müller, 2007). Evo-devo is considered a new rule in evolutionary biology and a complement to neo-Darwinian theories. It arose from the combination of developmental molecular biology and evolutionary molecular genetics; their integration greatly helped in understanding these two areas. Evo-devo, as a discipline, has explored the role of the individual developmental process and changes in the evolutionary phenotype, that is, the developmental procedure by which single-celled zygotes become multicellular organisms. Changes in the developmental program frequently result in differences in adult morphology. When these modifications are useful, they become fixed in a population and can lead to the evolution of new phyla. Evo-devo seeks to understand how new groups form by understanding how the method of development evolved in different lineages. In other words, evo-devo explains the interaction between phenotype and genotype (Hall, 2007). Explaining the morphological novelty of evolutionary origins is one of the intermediate challenges of current evolutionary biology and is closely related to a vigorous discussion of how to relate developmental biology to standard perspectives of evolutionary theory ( Laubichler, 2010). Much theoretical and experimental effort is devoted to new developments that have challenged biologists for over a hundred years, for example the basis of fish fins, the changing of fins into limbs, and the evolution of feathers. Developmental biology promises to make a major contribution to these...... middle of article ......is. Furthermore, the relationship between neo-Darwinian evolutionary theory and evo-devo is highly contested (Hoekstra and Coyne, 2007; Minelli, 2010). However, understanding of evo-devo methods and how the morphological characteristics of different species ultimately diverged is still relatively limited. Craig (2010) stated that this field has obviously contributed to the understanding of genes and subsequently to the understanding of morphological features of the evolution of complex organisms. Evo-devo's assertion that regulatory changes play a critical role in the evolution of the form has been largely confirmed. Evo-devo is becoming a conceptual hub for even broader integration of research areas in organismal biology, including genetics, ecology, paleontology, behavior, cognition and other areas (Gerd B Müller)