Benefits and risks of isoniazid: 1033 patients were studied to deduce the complications of isoniazid (INH). They received dINH for at least 18 months, with or without other medications. Of the 25 patients who developed hepatitis, only three cases were actually due to INH: (0.29%). There was also a case of chronic liver disease which could be due to isoniazid in 2 patients. The greatest concern related to isoniazid was the development of central nervous system disorders, primarily peripheral neuropathy, in 12 patients. However, this is not a great cause for concern since the study was published in 1978 and there are now medications available for treatment in combination with isoniazid to prevent peripheral neuropathy. Although isoniazid is safe, it is never taken alone. It is taken in combination with rifampicin, and of the 25 patients developing hepatitis, the majority of them (15) were due to rifampicin31. This is a higher percentage of 1.5%, but the value is not higher to consider rifampin dangerous. Overall, it was decided: “When the risk of hepatitis was compared with the risks of developing or dying from tuberculosis, it was found that the benefits of INH chemoprophylaxis outweighed the risks. »31This information was released by the government and was based on a sample size sample. in “1,033” people, isoniazid chemoprophylaxis was also used for 18 months; more than twice the length of time that isoniazid in combination with other drugs would be used in treatment today. Patients are therefore less likely to develop symptoms. Although this trial is old, it is very reliable because it has a large sample size and is unbiased because the information comes from a MEDLINE database. Additionally, since it was a large study, it can be assumed that it was done fairly and that there was... middle of paper... a lot of knowledge in the field required to write the book. Additionally, the publishers of this book, “Chelsea House Publisher,” are world-renowned and respected publishers and have published many award-winning titles. Another source I used was the journal article “Hydrogen Peroxide in the Human Body” by Barry Halliwell. This is a reliable source because the article has been peer-reviewed: a process that involves numerous professional reviewers examining the accuracy of the article's content and providing critiques. For the article to be published, reviewers must agree that the article is exceptional and fully accurate. Halliwell is a professor and holds a bachelor's degree in biomedicine from the University of Oxford. He headed the biochemistry department of a university and devoted much of his life to research. He is a very educated professor, which confirms that he is a reliable source.